2012 Fiscal Year Final Research Report
Renal hemodynamics affected by carbon dioxide-induced pnemoperitoneum
| Project/Area Number |
20591896
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya University |
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Principal Investigator |
HATTORI Ryohei 名古屋大学, 医学系研究科, 准教授 (20324410)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tokunori 名古屋大学, 大学院・医学系研究科, 准教授 (20182636)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 腹腔鏡手術 / 気腹圧 / 腎微小循環 |
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| Research Abstract |
We investigated the effect of pneumoperitoneum on the renal function. The erythrocyte velocity in the cortical peritubular capillary significantly decreased during increased carbon dioxide pneumoperitoneum in the porcine models and human laparoscopic surgery. We investigated the superficial oxygen concentration of the kidneys during laparoscopic surgery in 12mmHg (group A) or 8mmHg (group B) pneumoperitoneum. The oxygen concentration decreased 3 hours after the pnemoperitoneum in group A, while it was maintained in group B. We also investigated the renal function of the transplanted kidneys which had been harvested in laparoscopic donor nephrectomy. (group C in 12mmHg and group D in 8mmHg). ERPF of the group C recipients was 229±71ml/minon 1 week after transplant, while they were252±52ml/minin the group D. Renal microcirculation is affected by increased pneumoperitoneum. Renal function would be impaired after long time peumoperitoneum more than 12mmHg.
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