2010 Fiscal Year Final Research Report
Detection of HPV infection status from liquid based cytology specimens
| Project/Area Number |
20591948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Okayama University |
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Principal Investigator |
HONGO Atsushi Okayama University, 岡山大学病院, 講師 (10301293)
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| Project Period (FY) |
2008 – 2010
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| Keywords | HPV / IGF-I受容体 / p53 |
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| Research Abstract |
We found that infected HPV caused up-regulation of the insulin-like growth factor receptor in cervical cancer cell lines. By using this phenomenon, we evaluated expression levels and its localization of IGF-IR in human cervical cancer and its precursor lesions by immunohistochemistry. We could distinguish status of HPV infection by the localization of IGF-IR overexpression. Then we tried to utilize this technique in liquid based cytology specimens. However, we could not distinguish HPV infection status from cytology specimens.
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