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2010 Fiscal Year Final Research Report

Proteomic prediction of radiotherapy outcome in cervical cancer

Research Project

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Project/Area Number 20591956
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

ASATO Tsuyoshi  University of the Ryukyus, 大学院・医学研究科, 助教 (40253950)

Co-Investigator(Renkei-kenkyūsha) NAGAI Yutaka  琉球大学, 医学部附属病院, 講師 (70305209)
INAMINE Morihiko  琉球大学, 医学研究科, 助教 (90437989)
KARIYA Ken-Ichi  琉球大学, 医学研究科, 教授 (40263371)
Research Collaborator YAMASHIRO Yoshito  琉球大学, 医学研究科・博士課程, 日本学術振興会特別研究員
Project Period (FY) 2008 – 2010
Keywords子宮頸癌 / 放射線治療
Research Abstract

The present study was conducted in order to obtain data that serve as a basis for developing novel molecular markers for prediction of the outcome of radiotherapy in patients with cervical cancer. Subjects were selected from cases that were sensitive or resistant to the concurrent chemoradiotherapy (CCRT). Comprehensive protein expression profiles of pre-threapy biopsy specimen were compared between the sensitive and resistant cases. Eight proteins were identified that were expressed only in sensitive cases, while 18 proteins were identified that were expressed only in resistant cases.

  • Research Products

    (6 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma.2010

    • Author(s)
      Yoshito Yamashiro, Kimiko Takei, Masato Umikawa, Tsuyoshi Asato, Minoru Oshiro, Yukiko Uechi, Takahiro Ishikawa, Kiyohito Taira, Hiroshi Uezato, Ken-ichi Kariya
    • Journal Title

      Biochemical and Biophysical Research Communications 399

      Pages: 365-372

    • Peer Reviewed
  • [Journal Article] Impact of human papillomavirus genotype on response to treatment and survical in patients receiving radiotherapy for squamous cell carcioma of the cervix.2010

    • Author(s)
      Jannatul Ferdousi, Yutaka Nagai, Tsuyoshi Asato, Makoto Hirakawa, Morihiko Inamine, Wataru Kudaka, Ken-ichi Kariya, Yoichi Aoki
    • Journal Title

      Experimental and Therapeutic Medicine 1

      Pages: 525-530

    • Peer Reviewed
  • [Journal Article] Rap2 function requires palmitoylation and recycling endosome localization.2009

    • Author(s)
      Yukiko Uechi, Maitsetseg Bayarjargal, Masato Umikawa, Minoru Oshiro, Kimiko Takei, Yoshito Yamashiro, Tsuyoshi Asato, Shogo Endo, Ryo Misaki, Tomohiko Taguchi, Ken-ichi Kariya
    • Journal Title

      Biochemical and Biophysical Research Communications 378

      Pages: 732-737

    • Peer Reviewed
  • [Journal Article] MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1.2008

    • Author(s)
      Hideo Nonaka, Kimiko Takei, Masato Umikawa, Minoru Oshiro, Kouichi Kuninaka, Maitsetseg Bayarjargal, Tsuyoshi Asato, Yoshito Yamashiro, Yukiko Uechi, Shogo Endo, Tatsuo Suzuki, Ken-ichi Kariya
    • Journal Title

      Biochemical and Biophysical Research Communications 377

      Pages: 573-578

    • Peer Reviewed
  • [Presentation] The proteomic search for prognosis markers of cutaneous squamous cell carcinoma.2009

    • Author(s)
      Yoshito Yamashiro (代表発表者), Kimiko Takei, Masato Umikawa, Tsuyoshi Asato, Kiyohito Taira, Hiroshi Uezato, Ken-ichi Kariya
    • Organizer
      MBSJ2009(第32回日本分子生物学会年会)プログラム:3P-0743 : 418
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
  • [Presentation] Localization of Rap2 in recycling endosome in a palmitoylationdependent manner.2008

    • Author(s)
      Maitsetseg Bayarjargal (代表発表者), Yukiko Uechi, Shogo Endo, Kimiko Nonaka-Takei, Minoru Oshiro, Masato Umikawa, Tsuyoshi Asato, Yoshito Yamashiro, Tomohiko Taguchi, Ken-ichi Kariya
    • Organizer
      Biochemistry Molecular Biology (BMB) 2008(第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会)プログラム:1P-0444 : 219
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2008-12-09

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Published: 2012-01-26   Modified: 2016-04-21  

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