2010 Fiscal Year Final Research Report
The elucidation of the pathophysiology of Meniere's disease induced by the circadian rhythm disorder
| Project/Area Number |
20591978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gifu University |
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Principal Investigator |
AOKI Mitsuhiro Gifu University, 医学部附属病院, 講師 (30283302)
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| Project Period (FY) |
2008 – 2010
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| Keywords | メニエール病 / サーカディアンリズム / マウス / バゾプレッシン / コルチゾール / 聴力レベル / 内リンパ水腫 |
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| Research Abstract |
Intractable cases with Meniere's disease often show a disorder of circadian rhythm because of repeated vertigo attacks and severe tinnitus. In mouse model of Meniere's disease by chronic administration of arginin-vasopressin (AVP), the significant disorder of the circadian rhythm in the locomotion test was found in comparison with the control mouse by chronic administration of normal saline. In addition, the threshold in auditory brainstem response significantly increased during 2 weeks of administration of AVP. Our results suggest that the elevation of AVP in intractable cases with Meniere's disease induces the disorder of the circadian rhythm, resulting in affecting the prognosis of Meniere's disease.
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[Journal Article] Clinical characteristics of delayed endolymphatic hydrops in Japan : a nationwide survey by the Peripheral Vestibular Disorder Research Committee of Japan.2010
Author(s)
Shojaku H, Watanabe Y, Takeda N, Ikezono T, Takahashi M, Kakigi A, Ito J, Doi K, Suzuki M, Takumida M, Takahashi K, Yamashita H, Koizuka I, Usami S, Aoki M, Naganuma H.
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Journal Title
Acta Otolaryngologica 130
Pages: 1135-1140
Peer Reviewed
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