2010 Fiscal Year Final Research Report
Development of New Treatment Strategies for Chronic Rhinosinusitis Based on Epigenetic Analysis
| Project/Area Number |
20592004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
YOSHIKAWA Mamoru Jikei University School of Medicine, 医学部, 講師 (50277092)
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| Project Period (FY) |
2008 – 2010
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| Keywords | インターフェロン誘導性遺伝子 / ウィルス感染 / エピジェネティック解析 / 気管支喘息 / 慢性副鼻腔炎 |
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| Research Abstract |
As a results of investigation of clinical background concerning intractable chronic rhinosinusitis, we thought that nasal sinus mucosa differences in reactivity against virus infection exists. We verified whether or not the expression of IFN-induced genes such as IP-10 and I-TAC, compares the before and after the incubation with DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors. We identified that histone acetylation is involved in transcriptional regulation. We targeted to drug discovery for epigenetic control as effective therapy for intractable chronic rhinosinusitis in the future.
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