2010 Fiscal Year Final Research Report
New therapeutic approach for nasopharyngeal carcinoma using induction of Epstein-Barr virus lytic cycle by anti-cancer chemotherapy
| Project/Area Number |
20592012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa University |
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Principal Investigator |
MURONO Shigeyuki Kanazawa University, 附属病院, 講師 (20345622)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIZAKI Tomokazu 金沢大学, 医学系, 教授 (70262582)
WAKISAKA Naohiro 金沢大学, 附属病院, 講師 (70377414)
KONDO Satoru 金沢大学, 附属病院, 助教 (70436822)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 上咽頭癌 / 抗癌剤 / EBウイルス / 複製サイクル / ガンシクロビル |
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| Research Abstract |
Treatment of Epstein-Barr virus-positive epithelial cell lines with CDDP, one of anti-cancer drugs, induced BZLF1 protein, which play an important role in switching latent EBV infection to lytic cycle. No clear induction of apoptosis by the drug was observed. In the biopsy specimens taken from post-chemotherapy nasopharyngeal carcinoma patients, histological effect of chemotherapy was grade 0 or 1. On the other hand, immunohistochemistry for BZLF1 could not be properly performed.
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Research Products
(11 results)
