2010 Fiscal Year Final Research Report
Development of new cancer treatment using anticancer effect of D-allose
| Project/Area Number |
20592019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagawa University |
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Principal Investigator |
HOSHIKAWA Hiroshi Kagawa University, 医学部, 准教授 (70294767)
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| Research Collaborator |
MORI Terushige NTT西日本大阪病院, 耳鼻咽喉科
INDO Kanako 香川大学, 医学部・耳鼻咽喉科, 助教 (90380188)
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| Project Period (FY) |
2008 – 2010
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| Keywords | D-allose / anticancer effect / head and neck |
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| Research Abstract |
D-allose exerts growth inhibitory effects on head and neck cancer cells in vitro and in vivo. The combination of D-allose and radiation significantly induced intracellular reactive oxygen species (ROS) and apoptosis compared to that induced by either agent alone. The sugar may act as an anti-proliferative agent via TXNIP induction and thus be useful as a novel anticancer drug.
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