2010 Fiscal Year Final Research Report
Role of medullary interneurons in swallowing pattern generation
| Project/Area Number |
20592022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyushu University |
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Principal Investigator |
UMEZAKI Toshiro Kyushu University, 大学病院, 講師 (80223600)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Kazuo 九州大学, 大学病院, 助教 (90380386)
NAKAZAWA Ken 千葉大学, 医学系研究院, 講師 (10312943)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 嚥下 / fictive swallowing model / モルモット / ニューロビオチン / 孤束核 / 嚥下関連ニューロン / 軸索投射 |
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| Research Abstract |
To reveal the medullary neuronal network of the swallowing central pattern generator (CPG), we examined the cytoarchitecture of the swallowing CPG and axonal projections of its individual neurons by extracellular recording and juxtacellular labeling of swallowing-related neurons (SRNs) in the medulla in urethane-anesthetized and paralyzed guinea pigs. The SRNs in and around the NTS had axons projecting to the NTS, RF, nucleus ambiguus, nucleus hypoglossus, and dorsalmotor nucleus of the vagus on the ipsilateral side. These findings show anatomic substrates for the neuronal network of the CPG for swallowing, which consists of complex neuronal connections among SRNs in the NTS, RF, and motor nuclei.
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