The study for cell-cell interaction and molecular signals about maintenance of retina stem cell

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kumamoto University
• Principal Investigator: FUKUSHIMA Mikiko Kumamoto University, 大学院・生命科学研究部, 准教授 (10284770)
• Co-Investigator(Kenkyū-buntansha): INATANI Masaru 熊本大学, 医学部附属病院, 講師 (40335245) ; GYOUTOKU Yuji 熊本大学, 医学部附属病院, 助教 (10420639)
• Co-Investigator(Renkei-kenkyūsha): INOUE Toshihiro 熊本大学, 大学院・生命科学研究部, 助教 (00317025)
• Research Collaborator: INOUE Miyuki 熊本大学, 大学院・自然科学研究科, グローバルCOEリサーチアソシエイト
• Project Period (FY): 2008 – 2010
• Keywords: 再生医学 / 細胞・組織 / 神経科学

Research Abstract

The retinal tissue progenitor cell was analyzed as a basic research for the clinical application of the retina regeneration therapy. The search for the molecule was related to proliferation and differentiation of the retinal progenitor cell, and was analyzed by using the knockout mouse. Then it was clarified to the maintenance of the retinal progenitor cell of the role of the heparan sulfate proteoglycan, and relations of the molecular signal through gp130 for the differentiation.

Research Products

• [Journal Article] Dynamic imaging of axonal transport in living retinal ganglion cells in vitro. (2011)
  • Author(s): Takihara Y, Inatani M, Hayashi H, Adachi N, Iwao K, Inoue T, Iwao M, Tanihara H.
  • Journal Title: Invest Ophthalmol Vis Sci. 52 Pages: 3039-3045
• [Journal Article] Suppression of choroidal neovascularization by N-acetyl-cysteine in mice. (2010)
  • Author(s): Hara R, Inomata Y, Kawaji T, Sagara N, Inatani M, Fukushima M, Tanihara H.
  • Journal Title: Curr Eye Res. 35 Pages: 1012-1020
• [Journal Article] Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. (2010)
  • Author(s): Inoue T, Kagawa T, Inoue-Mochita M, Isono K, Ohtsu N, Nobuhisa I, Fukushima M, Tanihara H, Taga T.
  • Journal Title: FEBS Lett. 584 Pages: 3233-3238
• [Journal Article] Retinal astrocyte differentiation mediated by leukemia inhibitory factor in cooperation with bone morphogenetic protein 2. (2009)
  • Author(s): Fukushima M, Setoguchi T, Komiya S, Tanihara H, Taga T.
  • Journal Title: Int J Dev Neurosci. 27 Pages: 685-690
• [Journal Article] Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-eficient mice. (2009)
  • Author(s): Inomata Y, Fukushima M, Hara R, Takahashi E, Honjo M, Koga T, Kawaji T, Satoh H, Takeya M, Sawamura T, Tanihara H.
  • Journal Title: Invest Ophthalmol Vis Sci. 50 Pages: 3970-3976
• [Presentation] Heparan sulfate the key regulator of optic nerve guidance. (2009)
  • Author(s): Inatani M.
  • Organizer: Nakajima Award Lecture APSEG-molecular pathology I. APAO AAO Joint congress
  • Place of Presentation: Bali.
  • Year and Date: 2009-05-16