2010 Fiscal Year Final Research Report
Identification of human corneal limbal stem cell markers based on the method of epithelial cell-lineaged stem cell isolation
| Project/Area Number |
20592072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
YAMAGAMI Satoru Tokyo Women's Medical University, 医学部, 准教授 (10220245)
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| Co-Investigator(Kenkyū-buntansha) |
OKOO Seiichi 東京大学, 医学部, 特任研究員 (20345052)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 角膜上皮細胞 / 幹細胞 / ラミニン5 / 結膜上皮細胞 / 杯細胞 |
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| Research Abstract |
We tried to isolate human conjunctival epithelial progenitor cells using laminin-5 expressing highly adherent cells isolation method. As a result, we have isolated conjunctival epithelial progenitor cells, which could differentiate into epithelial cells and goblet cells. Our data suggest that we can identify isolation marker by comparing character between conjunctival and corneal limbal stem cells.
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[Journal Article] Human corneal endothelial cells expressing programmed death-ligand 1(PD-L1) suppress PD-1^+ T helper 1 cells by a contact-dependent mechanism.2009
Author(s)
Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami S
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Journal Title
Investigative Ophthalmology & Visual Science 50
Pages: 263-272
Peer Reviewed
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