2010 Fiscal Year Final Research Report
TPN administration lead to alteration of hepatocyte cell cycle and metabolic abnormalities in the mouse model with intestinal failure
| Project/Area Number |
20592094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Osaka University |
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Principal Investigator |
TAZUKE Yuko Osaka University, 医学部, 講師 (10397698)
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| Co-Investigator(Kenkyū-buntansha) |
KOSAKU Maeda 自治医科大学, 医学部, 教授 (60332756)
FUKUZAWA Masahiro 大阪大学, 医学部, 教授 (60165272)
OKUYAMA Hiroomi 兵庫医科大学, 医学部, 教授 (30252670)
FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腸管機能障害 / 中心静脈栄養 / 肝機能障害 / 細胞周期 |
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| Research Abstract |
The aim of this study was to test the hypothesis that PN administration in the mouse models with intestinal failure would lead to alteration of hepatocyte cell cycle and metabolic abnormalities of glucose and lipids and subsequently lead to an altered abundance of adipocytokines and their related gene expression in a rat model. This study also investigated whether some or all of these PN-associated metabolic abnormalities are related to parenteral lipid administration. The study shows that PN led to specific alterations in the abundance of adipocytokines and PPARs. These changes give critical insight into many of the metabolic derangements in lipid metabolism, which patients may experience with PN.
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