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2010 Fiscal Year Final Research Report

Treatment of infected wound with omentum-derived cells

Research Project

  • PDF
Project/Area Number 20592097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionNagoya University

Principal Investigator

KAMEI Yuzuru  Nagoya University, 医学系研究科, 教授 (10257678)

Co-Investigator(Kenkyū-buntansha) TORIYAMA Kazuhiro  名古屋大学, 大学院・医学系研究科, 准教授 (40314017)
YAGI Shunjirou  名古屋大学, 医学部附属病院, 講師 (00378192)
SATO Hideyoshi  名古屋大学, 医学部附属病院, 医員 (70528968)
Project Period (FY) 2008 – 2010
Keywords大網 / 筋弁 / 感染創モデル / 細胞治療 / 抗感染作用
Research Abstract

Muscle flaps and omental flaps are used for treatment of infected wound. We think omental flaps are more effective for infected wound than muscle flaps by our clinical experiences and previous experiments. However, there are few repots involving anti-infective effects of omental flaps. After we established a new infected wound model, we compared omental flaps to muscle flaps in this model. Furthermore, we investigated the anti-infective effects of omentum-derived cells. At first, we established a new stable infected wound model by the semi-fluid medium plus Staphylococcus aureus. When we compared omental flaps to muscle flaps in this model, a few muscle flaps responded to the infected wound. On the other hand, most omental flaps responded to the wound : omental flaps adhered the surrounding tissue and supplied a lot of inflammatory cells. When we injected the omentum-derived cells to the infected wound, these cells survived locally with neovascularization and were surrounded by a lot of inflammatory cells. Taken together, these findings indicate omental flaps are more effective for infected wound than muscle flap. There's a possibility that omentum-derived cells have the anti-infective effect for the infected wound.

  • Research Products

    (9 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Free Calvarial Periosteum Graft Vascularized by an Omental Flap in a Rat Model.2011

    • Author(s)
      Nakazato K, Toriyama K, Hishida M, Takanari K, Yagi S, Yamashita Y, Akatsuka S, Hayakawa A, Kamei Y.
    • Journal Title

      Ann Plast Surg.

    • Peer Reviewed
  • [Journal Article] Tissue-engineering bone from omentum.2010

    • Author(s)
      Kamei Y, Toriyama K, Takada T, Yagi S.
    • Journal Title

      Nagoya J Med Sci. 72(3-4)

      Pages: 111-117

    • Peer Reviewed
  • [Journal Article] Omental flap closure of refractory wounds : rat model.2010

    • Author(s)
      Hishida M, Toriyama K, Yamashita Y, Akatsuka S, Hayakawa A, Torii S, Kamei Y.
    • Journal Title

      Nagoya J Med Sci. 72(1-2)

      Pages: 91-99

    • Peer Reviewed
  • [Presentation] 感染創モデルを用いた大網弁の有用性の検討2011

    • Author(s)
      佐藤秀吉、鳥山和宏、八木俊路朗、蛯沢克己、小野昌史、神戸未来、亀井譲
    • Organizer
      第57回日本形成外科学会中部支部東海地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-19
  • [Presentation] ラット頭蓋骨骨膜を大網上に移植したときの骨誘導の検討2010

    • Author(s)
      中里公亮, 亀井譲, 鳥山和宏, 八木俊路朗, 高成啓介, 神山圭史, 鳥居修平
    • Organizer
      第19回日本形成外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20100916-20100917
  • [Presentation] 粘膜欠損に対する筋弁と大網弁の創傷治癒2010

    • Author(s)
      菱田雅之、鳥山和宏、山下依子、早川あけみ、八木俊路朗、亀井譲
    • Organizer
      第19回日本形成外科学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20100916-20100917
  • [Presentation] 感染創皮膚潰瘍モデルの作成2009

    • Author(s)
      鳥山和宏、亀井譲、八木俊路朗、高成啓介、鳥居修平
    • Organizer
      第18回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      20091001-20091002
  • [Presentation] Osteogenic potential of free calvarial periosteum graft on the greater omentum in rat model.

    • Author(s)
      鳥山和宏, 中里公亮, 亀井譲, 八木俊路朗, 佐藤秀吉, 小野昌史, 神戸未来
    • Organizer
      The 10^<th> Korea-Japan Congress of Plastic and Reconstructive Surgery.
  • [Presentation] Expression of TGF-beta and VGEF of cell proliferation and cytodifferentiation in the calvarial periosteum on an omental flap.

    • Author(s)
      鳥山和宏, 中里公亮, 亀井譲, 八木俊路朗, 佐藤秀吉, 小野昌史, 神戸未来
    • Organizer
      20^<th> Sino-Japan Joint Congress on Plastic Surgery

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Published: 2012-01-26   Modified: 2016-04-21  

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