2010 Fiscal Year Final Research Report
Expression of a lipid-metabolizing enzyme, diacylglycerol kinase, after brain damage
| Project/Area Number |
20592116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Kaoru 山形大学, 医学部, 教授 (30234975)
ISEKI Ken 山形大学, 医学部, 准教授 (70332921)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脳損傷 / 脂質代謝酵素 / ミクログリア |
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| Research Abstract |
Diacyglycerol kinase (DGK) plays an important role in the intracellular signal transduction through the metabolism of a second messenger diacylglycerol. One of the DGK isozymes, DGKζ was originally shown to be expressed in neurons under physiological conditions. However, we found that under pathological conditions, a cryoinjury brain model, DGKζ-immunoreactivity is detected in activated microglia that phagocytose the debris after brain injury. These results suggest that DGK. participates in the remodeling of the brain after injury.
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[Journal Article] NAP Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins2011
Author(s)
Okada M, Hozumi Y, Ichimura T, Tanaka T, Hasegawa H, Yamamoto M, Takahashi N, Iseki K, Yagisawa H, Shinkawa T, Isobe T, Goto K
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Journal Title
Exp Cell Res
Volume: 317
Pages: 2853-63
Peer Reviewed
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[Journal Article] Diacylglycerol kinase ζ is associated with chromatin, but dissociates from condensed chromatin during mitotic phase in NIH3T3 cells2008
Author(s)
Hasegawa H, Nakano T, Hozumi Y, Takagi M, Ogino T, Okada M, Iseki K, Kondo H, Watanabe M, Martelli AM, Goto K
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Journal Title
J Cell Biochem
Volume: 105
Pages: 756-65
Peer Reviewed
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