2010 Fiscal Year Final Research Report
Implication for long-term hypothermia of degradation of cytokine mRNA in endothelial cells stimulated with lipopolysaccharides
| Project/Area Number |
20592129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nihon University |
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Principal Investigator |
SAKURAI Atsushi Nihon University, 医学部, 助教 (40339320)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Kosaku 日本大学, 医学部, 准教授 (90260968)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 内皮細胞 / 長期低温 / 炎症 / LPS / IL-8 / mRNA安定性 |
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| Research Abstract |
This experimental study investigated the production of interleukin (IL)-8 protein and its mRNA expression and stability in endothelial cells stimulated by lipopolysaccharides (LPS) and undergoing long-term hypothermia. Under long-term hypothermia, IL-8 protein production was suppressed, while IL-8 mRNA was stabilized at the point of turn-over and expression increased. The potential of IL-8 production for the inflammatory stimulation in endothelial cells may persist during long-term hypothermia.
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