2010 Fiscal Year Final Research Report
Proteomic analysis for oral epithelial dysplasia/carcinoma in situ-Aiming to establish a diagnostic marker-
| Project/Area Number |
20592147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
IRIE Tarou Showa University, 歯学部, 講師 (00317570)
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| Co-Investigator(Kenkyū-buntansha) |
TACHIKAWA Tetsuhiko 昭和大学, 歯学部, 教授 (10085772)
YAMAMOTO Gou 昭和大学 (80384189)
ISOBE Tomohide 昭和大学 (40515855)
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| Co-Investigator(Renkei-kenkyūsha) |
YASYHARA Rika 昭和大学 (20453649)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 異形成 / 上皮内癌 / プロテオミクス |
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| Research Abstract |
We performed proteomic analysis for oral epithelial dysplasia by means of laser microdissection. As a results, protein expression level of alpha 1 globin, beta globin, S100 protein A9, keratin 6, 14 and H2A histone family were increased than that in normal mucosal epithelium. Moreover, we applied microscopy-based multicolor tissue cytometry to analysis of epithelial dysplasia with the use of these proteins as a maker for epithelial dysplasia. The possibility was indicated that this system could distinguish epithelial dysplasia quantitatively. Further development of this system, it is expected that the way of pathological diagnosis of precancerous lesions without subjectivity will be established.
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[Journal Article] Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma2008
Author(s)
Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I
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Journal Title
Cancer Sci 99(7)
Pages: 1390-400
Peer Reviewed
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[Remarks] ホームページ等
