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2010 Fiscal Year Final Research Report

Radiation effects in the Japanese medaka (Oryzias latipes)

Research Project

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Project/Area Number 20592201
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionHiroshima University

Principal Investigator

SAWAJIRI Masahiko  Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (20325195)

Co-Investigator(Kenkyū-buntansha) NOMURA Yuji  広島大学, 大学院・医歯薬学総合研究科, 助教 (80218370)
TAKINAMI Shuichi  北海道大学, 大学院・歯学研究科, 准教授 (60154952)
TANIMOTO Keiji  広島大学, 大学院・医歯薬学総合研究科, 教授 (10116626)
Project Period (FY) 2008 – 2010
Keywords実験腫瘍学 / がん治療 / メダカ咽頭歯骨
Research Abstract

In accord with recent biological analyses, medaka has been gained much attention as a model animal of human diseases whereby the genetic background of human diseases may be deduced. We investigated radiological effect on medaka with carbon ion and gamma ray irradiation. To establish the medaka as an animal model for irradiated bone response to evaluate the tolerance for and effectiveness of carbon ion radiation dose with bone metabolism. We irradiated whole body of medaka with carbon ions and gamma rays. Bone resorption in the pharyngeal bone was investigated by histological analysis. For histochemical localization of enzymatic activity of tartrate-resistant acid phosphatase (TRAP), the main marker of osteoclasts, were performed on sections of pharyngeal bone. The carbon ion irradiated medaka showed reduced size and number of osteoclast compared with the gamma ray. The TRAP activities of carbon ion irradiated osteoclasts were more suppressed than gamma ray irradiated medaka. Carbon ion irradiation had a more marked effect on osteoclast activity, and suppressed their maturation to a greater extent than gamma irradiation. These observations suggest that carbon ion irradiation induces differential modulation of osteoclast growth factor expression. Medaka shares many cellular and morphological aspects with mammals and that will allow experimental approaches to identify novel factors in bone biology under normal and pathological conditions.

  • Research Products

    (4 results)

All 2011 2009 2008

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Irradiation Effect on Osteoclastogenesis Stimulated by Breast Cancer Cell2011

    • Author(s)
      Sawajiri M., Nomura Y., Banik S, Nishikiori R., Sonoda Y., Tanimoto T.,
    • Journal Title

      Health Physics Journal in press

    • Peer Reviewed
  • [Presentation] 重粒子線の骨代謝におよぼす影響2009

    • Author(s)
      澤尻昌彦、野村雄二, 滝波修一, 谷本啓二
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
  • [Presentation] Osteoclasts in the Japanese Medaka (Oryzias latipes) after irradiation of carbon ion and gamma ray.2009

    • Author(s)
      Banik S., Sawajiri M., Takinami S., Nomura Y., Mizoe J., Tanimoto K.
    • Organizer
      The 17th International DentoMaxillofacial Radiology
    • Place of Presentation
      Amsterdam, Netherlands.
    • Year and Date
      2009-06-28
  • [Presentation] Expression of MMP-13 in chondroblast Cells and Rat Tibia after Exposure to Accelerated Carbon Ions or Gamma Rays.2008

    • Author(s)
      Banik S., Sawajiri M., Takinami S., Nomura Y., Mizoe J., Tanimoto K.
    • Organizer
      The 7th Asian Congress of Oral and Maxillofacial Radiology
    • Place of Presentation
      Nara, Japan.
    • Year and Date
      2008-11-20

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Published: 2012-01-26   Modified: 2016-04-21  

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