2010 Fiscal Year Final Research Report
Is transporters of scintigraphic agents useful as tumor makers
| Project/Area Number |
20592207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KAWABATA Yoshihiro Kagoshima University, 医学部・歯学部附属病院, 助教 (70274842)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tsuyoshi 鹿児島大学, 医歯学総合研究科, 准教授 (60098978)
MAJIMA Hideyuki 鹿児島大学, 医歯学総合研究科, 教授 (60165701)
SENBA Ichiro 鹿児島大学, 医歯学総合研究科, 教授 (60145505)
NAKAMURA Norifumi 鹿児島大学, 医歯学総合研究科, 教授 (60217875)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIMURA Ryozo 鹿児島大学, 医歯学総合研究科, 准教授
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腫瘍マーカー / 放射性薬品 / 輸送蛋白 / 口腔扁平上皮癌 / 免疫組織染色 / 核医学 |
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| Research Abstract |
Expression of transporters of scintigraphic agents on cell membrane was evaluated immunohistochemically using patients with squamous cell carcinoma in oral lesion and animal models with squamous cell carcinoma. Transport proteins of glucose transporter, P-glycoprotein, Na/K-ATPase and L-amino acid transporter found on cell membrane and showed a distinct correlation with tumor malignancy, tissue differentiation and accumulation of nuclear agents in tumor cells. These results indicated a possibility that transport proteins were useful as tumor marker for diagnosis of malignant tumors.
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