Development of adhesive system with capacity of self-repair applied by Sr-CaPO4 complex

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Hiroshima University
• Principal Investigator: SHIRAI Kenichi Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (20325179)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Shigeki 広島大学, 大学院・医歯薬学総合研究科, 助教 (30549762) ; NISHIMURA Fusanori 広島大学, 大学院・医歯薬学総合研究科, 教授 (80208222) ; SHIBATA Satoru 広島大学, 大学院・医歯薬学総合研究科, 助教 (20432693)
• Project Period (FY): 2008 – 2010
• Keywords: ストロンチウム / X線光電子分光分析装置 / リン酸カルシウム / 象牙質再石灰化 / 接着システム

Research Abstract

The aim of study is to develop adhesive system with the capacity of self-repair applied by Sr-CaPO4 complex, in order
1. to make of the best Sr-CaPO4 complex.
2. to make of experimentally adhesive system included Sr-CaPO4 complex.
3. to evaluate dentin re-calcification by Sr-CaPO4 complex and the experimental bonding system contained Sr-CaPO4 complex.
As a result, dentin re-calcification was possessed though the Sr calcium phosphate complex was not more significant than Sr and the Ca unit.

Research Products

• [Journal Article] 歯面コート材によるコーティングがもたらす歯質の脱灰抑制効果 (2010)
  • Author(s): 荒川真, 白井憲一, 鈴木茂樹, 本山直世, 山下明子, 峯岡茜, 藤井理史, 西村英紀
  • Journal Title: 日本歯科保存学雑誌 53 Pages: 73-78
• [Journal Article] Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation (2010)
  • Author(s): Sugiura Y., Soga Y., Yamabe K., Tsutani S., Tanimoto I., Maeda H., Kokeguchi S., Fujii N., Ishimaru F., Tanimoto M., Nishimura F., Takashiba S.
  • Journal Title: Supportive Care in Cancer 18 Pages: 395-398
  • Peer Reviewed
• [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy (2010)
  • Author(s): Cui X., Kushiyama A., Yoneda M., Nakatsu Y., Guo Y., Zhang J., Ono H., Kanna M., Sakoda H., Ono H., Kikuchi T., Fujishiro M., Shiomi M., Kamata H., Kurihara H., Kikuchi M., Kawazu S., Nishimura F., Asano T.
  • Journal Title: Diabetes Res Clin Pract 87 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1 (2010)
  • Author(s): Suzuki S., Kulkarni A.B.
  • Journal Title: Biochem Biophys Res Commun. 398(3) Pages: 525-531
  • Peer Reviewed
• [Journal Article] Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase (2010)
  • Author(s): Yoneda M., Guo Y., Ono H., Nakatsu Y., Zhang J., Cui X.L., Iwashita M., Kumamoto S., Tsuchiya Y., Sakoda H., Fujishiro M., Kushiyama A., Koketsu Y., Kikuchi T., Kamata H., Nishimura F., Asano T.
  • Journal Title: Obese Res Clin Pract 4 Pages: 201-207
  • Peer Reviewed
• [Journal Article] Clinical and immunological assessment of periodontal disease in Japanese leprosy patients (2010)
  • Author(s): Ohyama H., Hongyo H., Shimizu N., Shimizu Y., Nishimura F., Nakagawa M., Arai H., Kato-Kogoe N., Terada N., Nagai A., Takashiba S., Kurihara H., Nomura Y., Murayama Y.
  • Journal Title: Jpn J Infect Dis. 63 Pages: 427-432
  • Peer Reviewed
• [Journal Article] Synergistic Roles of Amelogenin and Ameloblastin. (2009)
  • Author(s): Hatakeyama J., Fukumoto S., Nakamura T., Haruyama N., Suzuki S., Hatakeyama Y., Shum L., Gibson C.W., Yamada Y., Kulkarni A.B.
  • Journal Title: J.Dent.Res. 88(4) Pages: 318-322
  • Peer Reviewed
• [Journal Article] Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. (2009)
  • Author(s): Suzuki S., Sreenath T., Haruyama N., Honeycutt C., Terse A.., Cho A., Kohler T., Muller R., Goldberg M., Kulkarni A.B.
  • Journal Title: Matrix Biol. 28(4) Pages: 221-229
  • Peer Reviewed
• [Journal Article] Genetic evidence for key roles of decorin and biglycan in dentin. (2009)
  • Author(s): Haruyama N., Sreenath T.L., Suzuki S., Yao X., Wang Z., Wang Y., Honeycutt C., Iozzo R.V., Young M.F., Kulkarni A.B.
  • Journal Title: Matrix Biol. 28(3) Pages: 129-136
  • Peer Reviewed
• [Presentation] Prevention of LPS-induced insulin resistance in adipose tissue by ARB (2010)
  • Author(s): Iwashita M., Kumamoto S., Asano T., Nishimura F.
  • Organizer: The 88^<th> International Association for Dental Research General Session
  • Place of Presentation: Barcelona
  • Year and Date: 20100714-20100717
• [Presentation] ARB attenuates LPS-induced inflammatory cytokine expression in LDLR KO mouse (2010)
  • Author(s): Kumamoto S., Iwashita M., Asano T., Nishimura F.
  • Organizer: The International and American Association for Dental Research
  • Place of Presentation: Barcelona
  • Year and Date: 20100714-20100717
• [Presentation] Periodontal tissue destruction is associated with high triglycerides in Japanese (2010)
  • Author(s): Yamashita A., Katano M., Takagi M., Nishimura F.
  • Organizer: The International and American Association for Dental Research
  • Place of Presentation: Barcelona
  • Year and Date: 20100714-20100717
• [Presentation] Valsartan suppresses inflammatory response of LPS-induced activated macrophages and thereby improves adipose insulin resistance (2010)
  • Author(s): Iwashita M., Kumamoto S., Kushiyama A., Nakatsu Y., Tsuchiya Y., Sakoda H., Fujishiro M., Otani Y., Kikuchi T., Nishimura F., Kamata H., Asano T.
  • Organizer: American Diabetes Association 70^<th> Scientific Sessions
  • Place of Presentation: Orlando, Florida
  • Year and Date: 20100625-20100629
• [Presentation] Involvement of infiltrated macrophage in the induction of LPS-induced insulin resistance in adipose tissue and its prevention by ARB (2010)
  • Author(s): Iwashita M., Kumamoto S., Asano T., Nishimura F.
  • Organizer: The 2^<nd> International Workshop on BioDental Education & Research
  • Place of Presentation: Hiroshima
  • Year and Date: 20100211-20100212
• [Remarks] ホームページ等