2010 Fiscal Year Final Research Report
The relationships between hypermethylation of promotor region of tumor suppressor gene in serum of oral squamous cell carcinoma patients and clinical features
| Project/Area Number |
20592324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
YAMASHITA Tomomi Gifu University, 医学系研究科, 准教授 (80345793)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Keizo 岐阜大学, 医学部附属病院, 講師 (40397336)
MAKITA Hiroki 岐阜大学, 医学部附属病院, 講師 (50345790)
HATAKEYAMA Kaijiro 岐阜大学, 医学部附属病院, 助教 (40397336)
SHIBATA Toshiyuki 岐阜大学, 医学系研究科, 教授 (40397336)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 口腔癌 / 血清 / 血漿 / メチル化異常 |
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| Research Abstract |
Hypermethylation of promotor region of tumor suppressor gene in serum of oral squamous cell carcinoma patients before the tumor extirpation was p16 ; 66.7%, MGMT ; 14.3%, RECK ; 4.8%, CDH1 and TIMP-3 ; 0%.
The cases of hypermethylation of promotor region of p16 in serum before the tumor extirpation were investigated about hypermethylation of p16 in serum 3 months after the tumor extirpation. Hypermethylation of p16 was detected in patients with cancer and non-tumor-bearing patients. Hypermethylation of promotor region of p16 did not change before and after the tumor extirpation in serum of oral squamous cell carcinoma patients.
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