2010 Fiscal Year Final Research Report
The difference of nature and functional role between tumor-nest versus tumor-stroma infiltrating lymphocytes in oral cancer.
Project/Area Number |
20592325
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
KATOU Fuminori Hamamatsu University School of Medicine, 医学部, 准教授 (60204492)
|
Co-Investigator(Kenkyū-buntansha) |
WATANABE Yoshiko 浜松科大学, 医学部, 助教 (10444358)
|
Project Period (FY) |
2008 – 2010
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Keywords | 口腔癌 / リンパ球 |
Research Abstract |
We identified the tumor-nest and tumor-stroma infiltrating lymphocytes, and examined their functional role and activation status. In the tumor nest inhibitory CD8+ CTLs were abundant, but in the tumor stroma they were scarce. On the contrary, activated CD8+ CTLs and CD4+ T cells plentifully infiltrated to the tumor stroma.
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