The difference of nature and functional role between tumor-nest versus tumor-stroma infiltrating lymphocytes in oral cancer.
| Project/Area Number |
20592325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KATOU Fuminori Hamamatsu University School of Medicine, 医学部, 准教授 (60204492)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yoshiko 浜松科大学, 医学部, 助教 (10444358)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔癌 / リンパ球 / NK細胞 / 樹状細胞 / 活性化 |
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| Research Abstract |
We identified the tumor-nest and tumor-stroma infiltrating lymphocytes, and examined their functional role and activation status. In the tumor nest inhibitory CD8+ CTLs were abundant, but in the tumor stroma they were scarce. On the contrary, activated CD8+ CTLs and CD4+ T cells plentifully infiltrated to the tumor stroma.
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Report
(4 results)
Research Products
(5 results)
