2010 Fiscal Year Final Research Report
Effects of anticancer drug and angiogenesis inhibitor on invasion and metastasis of oral squamous cell carcinoma.
| Project/Area Number |
20592357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
KAWASHIRI Shuichi Kanazawa University, 附属病院, 講師 (30291371)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Etsuhide 金沢大学, 医学系, 教授 (00092445)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 抗癌剤 / 血管新生阻害薬 / 口腔扁平上皮癌 / 浸潤 / 転移 |
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| Research Abstract |
Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and angiogenesis inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OSC-19, was implanted into the tongue or oral floor of nude mice, and cisplatin or tranilast were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasiswere investigated. Tumor size and the ratio of proliferating cell nuclear antigen positive cells were significantly reduced. In the control group, the tumors showed grade 4C of mode of invasion, while in the groups treated with anticancer agent and angiogenesis inhibitor, grade 3 was observed, with an inhibitory effect on tumor invasion being observed. The rate of metastasis in the cervical lymph node was significantly decreased in the groups treated with the anticancer agent and angiogenesis inhibitor. The tumor stage progression in the metastatic lymph nodes was also inhibited. The use of anticancer agent and angiogenesis inhibitor considering these effects may be clinically very useful.
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[Journal Article] Integrin expression levels correlate with inva sion, metastasis and prognosis of oral squamous cell carcinoma.2009
Author(s)
Ohara T, Kawashiri S, Tanaka A, Nogu chi N, Kitahara H, Okamune A, Kato K, Hase T, Nakaya H, Yamamoto E
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Journal Title
Pathology and Oncology Research 15
Pages: 429-436
Peer Reviewed
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[Presentation] 口腔扁平上皮癌におけるMapin発現とuPA/uPAR発現-浸潤様式と予後との関連について-2011
Author(s)
吉澤邦夫, 能崎晋一, 八木瑞希, 木村依世, 杉浦史郎, 岡宗絢子, 北原寛子, 加藤広禄, 野口夏代, 川尻秀一, 中川清昌, 山本悦秀
Organizer
第29回日本口腔腫瘍学会総会
Place of Presentation
崇城大学市民ホール(熊本県)
Year and Date
2011-01-27
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[Presentation] ワークショップ『高悪性度口腔癌は克服できたか』癌浸潤様式4D型の生物学的性状2008
Author(s)
川尻秀一, 田中彰, 野口夏代, 中谷弘光, 加藤広禄, 長谷剛志, 吉澤邦夫, 大原照比差, 北原寛子, 岡宗絢子, 能崎晋一, 山本悦秀
Organizer
第46回日本癌治療学会総会
Place of Presentation
名古屋国際会議場(愛知県)
Year and Date
2008-10-31
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