2010 Fiscal Year Final Research Report
Angiogenin-induced differentiation of endothelial progenitor cell and the mechanism of tumor angiogenesis
| Project/Area Number |
20592359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KISHIMOTO Koji Okayama University, 大学院・医歯薬学総合研究科, 助教 (40243480)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Akira 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00170663)
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| Project Period (FY) |
2008 – 2010
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| Keywords | angiogenin / 血管内皮前駆細胞 / 血管新生 / 分化誘導 / 癌 |
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| Research Abstract |
Angiogenic factor, angiogenin underwent nuclear translocation in endothelial progenitor cell (EPC) in a cell density-independent manner and induced ribosome biogenesis, and cell proliferation. Angiogenin also increased EPC migration and invasion into the oral squamous cell carcinoma cell clusters. Moreover, various angiogenic factors such as bFGF and VEGF stimulated nuclear accumulation of endogenous angiogenin in EPC. These results suggest that angiogenin plays an important role in the tumor angiogenesis by EPC.
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