2010 Fiscal Year Final Research Report
Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic Patients
| Project/Area Number |
20592428
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
NARUISHI Koji Okayama University, 歯学部, 准教授 (00346446)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HATANAKA Kazu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (50362992)
TAKASHIBA Syougo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
MINESHIBA Junji 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00509383)
OMORI Kazuhiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20549860)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 糖尿病 / MMP-3 / 歯周病悪化 |
|---|
| Research Abstract |
Diabetic patients are susceptible to severe inflammatory periodontitis. In the present study, we found that high glucose increased MMP-3, but not sIL-6R production in gingival fibroblasts. In addition, sIL-6R production was suppressed by MMP-3 inhibitor in THP-1 macrophages. These results suggest that MMP-3 has a key role in developing severe periodontitis in diabetic patients. Furthermore, it has been considered that IL-6 signals are very important factor surrounding gingival fibroblasts/macrophage interaction in severe periodontitis seen in diabetic patients.
|
