2010 Fiscal Year Final Research Report
Bovine lactoferrin-based agents which promotes healing of tooth socket
| Project/Area Number |
20592433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
NAKASHIMA Keisuke Kyushu Dental College, 歯学部, 准教授 (80227785)
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| Co-Investigator(Kenkyū-buntansha) |
ABIKO Yoshihiro 北海道医療大学, 個体差医療科学センター, 教授 (90260819)
TAKAYAMA Yoshiharu 農業・食品産業技術総合研究機構, 畜産草地研究所, 主任研究員 (00343989)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 外科 / 歯学 / 生体分子 / タンパク質 / 動物 |
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| Research Abstract |
Effects of lactoferrin on healing of tooth socket were evaluated in this investigation. Right lower first molar of 4 weeks-old Wistar male rats was extracted under general anesthesia. Collagen sponge containing controlled-released bovine lactoferrin was inserted in the tooth socket. One week later, the rats were sacrificed. Healing of tooth socket was evaluated with 3-D images and histological images. Results of the investigation showed that controlled-released bovine lactoferrin decreases the number of neutrophils under the gingival epithelium and increase new bone formation.
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