Development of a new tooth coating with anti-carious and anti-periodontitis properties by using nanoparticles of Calcium Titanate

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592454
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: KISHIMOTO Etsuo Okayama University, 大学院・医歯薬学総合研究科, 准教授 (20091316)
• Co-Investigator(Kenkyū-buntansha): NAGAI Noriyuki 岡山大学, 名誉教授 (90085770) ; NAGATSUKA Hitoshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70237535) ; TAKAGI Shin 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40116471) ; TSUJIGIWA Hidetsugu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70335628) ; NAGAOKA Noriyuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (70304326)
• Project Period (FY): 2008 – 2010
• Keywords: チタン酸 / ナノ粒子 / 生体材料 / 齲蝕 / 歯周病 / 抗菌

Research Abstract

The objective of this study was the development of a new tooth coating method for prevention of caries and periodontitis by using calcium titanate nanoparticles. KUSA/A1 cells culture with CaTiO3-C showed good results for cell proliferation and differentiation. Furthermore, we have been able to produce CaTiO3-C with antibiotic properties that gave satisfying results against carious bacteria. We expected that this new coating material could be of a great utility in the future

Research Products

• [Journal Article] Effect of CaTiO(3)-CaCO(3) prepared by alkoxide method on cell response. (2010)
  • Author(s): Rodriguez AP, Inoue M, Tanaka T, Miyake M, Sfer AM, Kishimoto E, Tsujigiwa H, Rivera RS, Nagatsuka H.
  • Journal Title: J Biomed Mater Res A. 93(1) Pages: 297-303
  • Peer Reviewed
• [Journal Article] Effect of a new titanium coating material (CaTiO3-aC) prepared by thermal decomposition method on osteoblastic cell response. (2010)
  • Author(s): Inoue M, Rodriguez AP, Takagi T, Katase N, Kubota M, Nagai N, Nagatsuka H, Inoue M, Nagaoka N, Takagi S, Suzuki K.
  • Journal Title: J Biomater Appl. 24(7) Pages: 657-672
  • Peer Reviewed
• [Journal Article] Chemical Analysis of a Novel Coating Material, CaTiO3-aC. (2008)
  • Author(s): Okauchi-Yabuuchi M, Tamamura R, Nagaoka N, Takagi S, Kishimoto E, Takagi T, Rodriguez A, Inoue M, Nagatsuka H, Akao M, Nagai N.
  • Journal Title: Journal of Hard Tissue Biology. 17(3) Pages: 115-120
  • Peer Reviewed
• [Presentation] 骨髄幹細胞の歯・骨組織構成細胞への分化能についての検討 (2010)
  • Author(s): 辻極秀次
  • Organizer: 第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-22
• [Presentation] 新規コーティング材CaTiO3-aCの細胞生物学的・組織学的検討 (2010)
  • Author(s): 平田泰久
  • Organizer: 第19回硬組織再生生物学会・学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2010-09-04
• [Presentation] 新規生体材料チタン酸カルシウム-炭酸カルシウム(CaTiO3-CaCO3)の細胞学的検討 (2009)
  • Author(s): 井上美穂
  • Organizer: 第51回歯科基礎医学会学術大会・総会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-11
• [Presentation] Effect of carbon in CaTiO3 materials on cell proliferation and differentiation for medical application. (2008)
  • Author(s): A.Rodrigues
  • Organizer: The 4th International Symposium on Apatite and Correlative Biomaterials
  • Place of Presentation: Philippines
  • Year and Date: 2008-09-10