2010 Fiscal Year Final Research Report
The attenuation mechanism of bradykinin B2 receptor desensitization through prostaglandin EP3 receptor
| Project/Area Number |
20602007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
KOZAKI Yasuko Kinjo Gakuin University, 薬学部, 准教授 (20126882)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Yayoi 金城学院大学, 薬学部, 教授 (00117847)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUMURA Kazue 名古屋大学, 環境医学研究所, 教授 (00109349)
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| Project Period (FY) |
2008 – 2010
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| Keywords | プロスタグランジンEP3受容体 / ブラジキニンB2受容体 / 脱感作 / 痛覚過敏 / 受容体内在化 |
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| Research Abstract |
Repeated administration of bradykinin (BK), which is one of the endogenous algesic substances, induces desensitization of B2 receptor. Activation of prostaglandin (PG) E2 EP3 receptor attenuates B2 receptor desensitization, leading to increased pain. Our findings indicate a possibility that prostaglandin enhances both internalization of B2R bound to BK and recycling of the internalized bradykinin B2R through EP3R, and this might be a mechanism for sensitizing the BK response of nociceptors by prostaglandin E2.
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[Journal Article] Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed onset muscle soreness.2009
Author(s)
Murase S., Terazawa E., Queme F., Hiroki Ota H., Matsuda T., Hirate K., Kozaki Y., Katanosaka K., Taguchi T., Mizumura K.
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Journal Title
J.Neurosci. 30(10)
Pages: 3752-3761, DOI:10.1523/JNeurosci.3803-09.2010
Peer Reviewed
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