2010 Fiscal Year Final Research Report
Study of the nerve regeneration in neuropathic pain models by using fluorescent protein-expressing mice
| Project/Area Number |
20602013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kansai Medical University |
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Principal Investigator |
UNEZAKI Sawako Kansai Medical University, 医学部, 助教 (50257911)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Seiji 関西医科大学, 医学部, 教授 (80201325)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経再生 / イメージング |
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| Research Abstract |
We created a peripheral nerve regeneration model by using a thy1-YFP transgenic mice, which express a fluorescent protein (YFP) in their sensory/motor neurons. By monitoring sequentially and noninvasively the foot dorsal cutaneous innervation by in vivo fluorescence imaging, we could evaluate the effect of various factors in nerve regeneration. In these factors, we found that Nax, a sodium channel, is functionally coupled to endothelin for lactate release and involves peripheral nerve regeneration.
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