2010 Fiscal Year Final Research Report
Proteomic analysis for mechanisms of neuropathic pain
| Project/Area Number |
20602015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KATANO Tayo Kansai Medical University, 医学部, 助教 (60469244)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Shinji 関西医科大学, 医学部, 講師 (70276393)
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| Project Period (FY) |
2008 – 2010
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| Keywords | NR2B / プロテオミクス / リン酸化 |
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| Research Abstract |
Chronic pain is maintained by plastic change to synapse in the spinal dorsal horn. We previously clarified that the phosphorylation of Y1472 NR2B is important for neuropathic pain. In the present study, we determined the phosphorylation cascade through activation of CaMKII and identified two molecules as changing volume of protein after SNI in the postsynaptic density fraction by proteomic analysis using Y1472F KI mice, which have a knock-in mutation of the Tyr1472 site to phenylalanine, as comparison subject.
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[Journal Article] Involvement of stem cell factor and its receptor tyrosine kinase c-kit in pain regulation.2008
Author(s)
Takagi K., Okuda-Ashitaka E., Mabuchi T., Katano T., Ohnishi T., Matsumura S., Ohnaka M., Kaneko S., Abe T., Hirata T., Fujiwara S., Minami T., Ito S.
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Journal Title
Neuroscience 153
Pages: 1278-1288
Peer Reviewed
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