2010 Fiscal Year Final Research Report
Studies on the Molecular Recognition and Design of Ligands of Olfactory Receptors
| Project/Area Number |
20611018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
ISHIGURO Masaji Nigata University of Phermacy and Applied Life Sciences, 応用生命科学部, 教授 (10280687)
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| Co-Investigator(Kenkyū-buntansha) |
YONEDA Teruyo 新潟薬科大学, 応用生命科学部, 准教授 (30265714)
TAMIYA Minoru 新潟薬科大学, 応用生命科学部, 助教 (10468960)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 匂い受容体 / GPCR / フルアゴニスト / CH-π相互作用 / デヒドロエピアンドロステノン / ステロイド / OR7D4 / アンドロステノン |
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| Research Abstract |
Various odorants are recognized by about 500 kinds of odorant receptors. OR7D4, an odorant receptor binds androstadiene, a steroid derivative. Through modeling of the receptor-ligand complex structure, important residues involved in the ligand binding and the moieties which interact with the residues are selected and the steroid derivatives modified at the D16 portion were synthesized from dehydroepiandrosterone.
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