2011 Fiscal Year Final Research Report
Development of in situ measurement technique to evaluate the internal stress of intracellular structures
| Project/Area Number |
20680025
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
NAGAYAMA Kazuaki 名古屋工業大学, 大学院・工学研究科, 准教授 (10359763)
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| Project Period (FY) |
2008 – 2011
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| Keywords | バイオメカニクス / 生物・生体工学 / メカノトランスダクション / 細胞骨格 |
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| Research Abstract |
The purpose of this study is to elucidate how forces applied to cells are transmitted through intracellular components. We found that cytoskeletal filaments, such as actin stress fibers(SFs) and microtubules, have crucial roles in maintaining whole cell mechanical properties, and they contribute to the intracellular force balance three dimensionally, which control the internal tension of cells and their three dimensional morphology. We also found that SFs firmly connected to nuclear membrane, and the internal force of SFs transmitted mechanically to the nuclear membrane. These direct force transmission may induce the conformation changes of intranuclear DNA. The results of this study will provide new prospects in cellular mechanotransduction.
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