2010 Fiscal Year Final Research Report
Multiple layers of regulatory machineries for actin cytoskeleton at the leading edge
Project/Area Number |
20687012
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Cell biology
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Research Institution | The University of Tokyo |
Principal Investigator |
SUETSUGU Shiro The University of Tokyo, 分子細胞生物学研究所, 准教授 (70345031)
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Project Period (FY) |
2008 – 2010
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Keywords | 細胞骨格 / 細胞膜 / 細胞運動 / 細胞内情報伝達 / 浸潤 |
Research Abstract |
The I-BAR domain of IRSp53 deforms plasma membrane into protrusion through its binding of its convex surface to the inner surface of tubular protrusions. In contrast, the F-BAR domain of pacsin2 deforms plasma membrane at the neck of the protrusions, where orthogonal membrane curvature is formed by the concave surface of the F-BAR domain. These two modes of plasma membrane deformation are thought to be important for cellular protrusions including podosome for cancer cell invasion.
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[Journal Article] Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation.2010
Author(s)
Takano, K., Watanabe-Takano, H., Suetsugu, S., Kurita, S., Tsujita, K., Kimura, S., Karatsu, T., Takenawa, T., Endo, T.
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Journal Title
Science 330(6010)
Pages: 1536-1540
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[Journal Article] Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II.2010
Author(s)
Shimada, A., Takano, K., Shirouzu, M., Hanawa-Suetsugu, K., Terada, T., Toyooka, K., Umehara, T., Yamamoto, M., Yokoyama, S., Suetsugu, S.
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Journal Title
FEBS Lett 584(6)
Pages: 1111-1118
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[Journal Article] Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles.2009
Author(s)
Taniguchi, K., Takeya, R., Suetsugu, S., Kan, O.M., Narusawa, M., Shiose, A., Tominaga, R., Sumimoto, H.
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Journal Title
J Biol Chem 284(43)
Pages: 29873-29881
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[Journal Article] G-actin regulates rapid induction of actin nucleation by mDia1 to restore cellular actin polymers.2008
Author(s)
Higashida, C., Suetsugu, S., Tsuji, T., Monypenny, J., Narumiya, S., Watanabe, N.
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Journal Title
J Cell Sci 121(Pt 20)
Pages: 3403-3412
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