2011 Fiscal Year Final Research Report
Development of gene therapy for vascular disease using multi-functional polymeric micellar gene vector
| Project/Area Number |
20689024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Nagasaki University (2010-2011)
The University of Tokyo (2008-2009) |
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Principal Investigator |
OBA Makoto 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20396716)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 血管外科学 / 遺伝子治療 / ドラッグデリバリーシステム |
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| Research Abstract |
I developed systemic gene delivery systems for vascular diseases using polymeric micelles, composed of poly(ethylene glycol)-polycation block copolymers and plasmid DNA. I designed polymeric micelles with various intelligent functions, and they achieved an enhancement of stability in blood stream, targeting to disease regions, controlling intracellular trafficking, and effective release of encapsulated gene.
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[Journal Article] Polyplex micelles prepared fromω-cholesteryl PEG-polycation block copolymers for systemic gene delivery2011
Author(s)
M. Oba, K. Miyata, K. Osada, R. J. Christie, M. Sanjoh, W. Li, S. Fukushima, T. Ishii, M. R. Kano, N. Nishiyama, H. Koyama, K. Kataoka
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Journal Title
Biomaterials
Volume: 32(2)
Pages: 652-663
Peer Reviewed
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[Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue2008
Author(s)
K. Miyata, M. Oba, M. R. Kano, S. Fukushima, Y. Vachutinsky, M. Han, H. Koyama, K. Miyazono, N. Nishiyama, K. Kataoka
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Journal Title
Pharm. Res
Volume: 25(12)
Pages: 2924-2936
Peer Reviewed
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