2009 Fiscal Year Final Research Report
Analysis of Drosophila dPQBP1 mutant
| Project/Area Number |
20700285
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAMURA Takuya Tokyo Medical and Dental University, 難治疾患研究所, 助教 (80396647)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ショウジョウバエ / 記憶 / 学習 / 精神遅滞 / モデル動物 / PQBP1 / projection neuron |
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| Research Abstract |
We analyzed the dPQBP1 mutant to elucidate the cause of the inhibited learning acquisition of the dPQBP1 mutant. The dPQBP1 mutant has a defect in projection neurons but not in mushroom bodies (which is a target of projection neuron and which is considered to be center of memory). The defect was considered to be functional but not morphological (and/or developmental). It was suggested that the defect is depends on reduced expression of NMDA receptor in projection neurons.
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Research Products
(9 results)
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[Journal Article] These authours equally contribute Mutant huntingtin impairs Ku70-mediated DNA repair.2010
Author(s)
Enokido Y*, Tamura T*, Ito H*, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H
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Journal Title
J Cell Biol. 189(3)
Pages: 425-43
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[Journal Article] Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.2009
Author(s)
Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y
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Journal Title
PLoS One 4(2)
Pages: e4466
Peer Reviewed
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