2010 Fiscal Year Final Research Report
Functional analysis of RNA-binding protein Musashi2 in the nervous system
| Project/Area Number |
20700297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Keio University |
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Principal Investigator |
KUWAKO Ken-ichiro Keio University, 医学部, 助教 (30468475)
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| Project Period (FY) |
2008 – 2010
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| Keywords | RNA結合蛋白質 / 神経回路形成 |
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| Research Abstract |
We demonstrate that the expression of Slit receptor Robo3 is regulated by a neural RNA-binding protein Musashi (Msi). Msi binds to Robo3 mRNA and increases its translation. In Msi-deficient precerebellar neurons, Robo3 protein is dramatically reduced. Moreover, axonal midline crossing of precerebellar neurons are severely impaired in Msi-deficient mice.
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