2009 Fiscal Year Final Research Report
Regulation of neuronal regeneration by chondroitin sulfate
| Project/Area Number |
20700318
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
SOTOGAKU Naoki Kurume University, 医学部, 講師 (60368884)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 神経再生 / 神経可塑性 |
|---|
| Research Abstract |
Chondroitin sulfate (CS) is an important component of the cell surface and extracellular matrix in the central nervous system. CS is divided into at least four subclasses, known as CS-A, CS-C, CS-D and CS-E, on the basis of the sulfation patterns of their major disaccharide units. The CS-E polysaccharide, but not CS-A, CS-C or CS-D polysaccharide, was changed cell adhesion of neural stem cells. Several genes including H2-Q6 (histocompatibilty 2, class I antigen) and CCL12 (chemokine (C-C motif) ligand 12) were enhanced mRNA levels in CS-E polysaccharide-treated neural stem cells.
|
-
[Journal Article] Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum2008
Author(s)
Nish A, Kuroiwa M, Miller DB, O' Callaghan JP, Bateup HS, Shuto T, Sotogaku N, Fukuda T, Heintz N, Greengard P, Snyder GL
-
Journal Title
J Neurosci 28
Pages: 10460-10471
-
-
-
-
