2009 Fiscal Year Final Research Report
Identification of cell adhesion and receptor molecules which regulate presynaptic differentiation
| Project/Area Number |
20700329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YOSHIDA Tomoyuki The University of Tokyo, 大学院・医学系研究科, 講師 (90372367)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 発生 / 分化 / 老化 |
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| Research Abstract |
Functional screening of transmembrane proteins for their role in presynaptic differentiation of zebrafish olfactory sensory neurons identified IL1RAPL1. We demonstrated that zebrafish orthologue of mammalian IL1RAPL1, Il1rapl 1b, played an important role in axon terminal differentiation by regulating synaptic vesicle accumulation and morphological remodeling. We also showed that IP3-mediated Ca2+/calmodulin signaling stimulates synaptic vesicle accumulation and subsequent neuronal activity-dependent Ca2+/calmodulin signaling induces the morphological remodeling of axon terminals of zebrafish olfactory sensory neurons.
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