2010 Fiscal Year Final Research Report
Cooperative functions of PRMTs in neuronal differentiation.
| Project/Area Number |
20700335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
MIYATA Shingo Osaka University, 大学院・医学系研究科, 助教 (70403194)
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| Project Period (FY) |
2008 – 2010
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| Keywords | protein methylation / neurite outgrowth / immediately early gene / PRMT1 / CARM1 / Btg2 / Neuro2a cells / RNAi |
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| Research Abstract |
Neurite outgrowth is extremely important for the formation of the neuronal circuit. Recent progress in understanding the nature of protein arginine N-methyltransferases (PRMTs) have given rise to the possibility that protein methylation plays an important role in signal transduction during neuronal differentiation. In this study, we show that protein arginine methylation plays a pivotal role in neurite outgrowth.
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Research Products
(38 results)
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[Journal Article] Plasma Corticosterone Activates SGK1 and Induces Morphological Changes in Oligodendrocytes in Corpus Callosum.2011
Author(s)
Miyata S*(First author & corresponding author), Koyama Y, Takemoto K, Yoshikawa K, Ishikawa T, Taniguchi M, Inoue K, Aoki M, Hori O, Katayama T, Tohyama M.
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Journal Title
Peer Reviewed
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[Journal Article] bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing.2010
Author(s)
Kanazawa S, Fujiwara T, Matsuzaki S, Shingaki K, Taniguchi M, Miyata S, Tohyama M, Sakai Y, Yano K, Hosokawa K, *Kubo T.
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Journal Title
PLoS One. 5(8)
Pages: 12228
Peer Reviewed
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[Journal Article] Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain.2010
Author(s)
Okuda H, Kuwahara R, Matsuzaki S, Miyata S, Kumamoto N, Hattori T, Shimizu S, Yamada K, Kawamoto K, Hashimoto R, Takeda M, Katayama T, Tohyama M.
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Journal Title
PLoS One 5(1)
Pages: 8773
Peer Reviewed
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[Journal Article] A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome.2008
Author(s)
Bassuk A, Wallace R, Buhr A, Buller A, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach H, Shu W, Nashelsky M, Vladar E, Antic D, Ferguson P, Cirak S, Voit T, Scott M, Axelrod J,Gurnett C, Daoud A, Afawi Z, NeufeldM, Korczyn A, Kivity S, Mazarib A, Straussberg R, Walid S, Slusarski D, Berkovic S, El-Shanti H.
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Journal Title
American Journal of Human Genetics. 83
Pages: 572-581
Peer Reviewed
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