The role of Slit in migration of new neurons in the adult brain under physiological and pathological conditions.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20700337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya City University
• Principal Investigator: KANEKO Naoko Nagoya City University, 大学院・医学研究科, 助教 (20464571)
• Project Period (FY): 2008 – 2010
• Keywords: 発生 / 分化 / 老化

Research Abstract

New neurons are continuously generated in the mammalian subventricular zone, which migrate for a long distance through the meshwork of astrocytic processes toward the olfactory bulb. The molecular mechanism that regulates the interaction between the migrating neurons and surrounding astrocytes had been unknown. In this study, we demonstrated that the new neurons use a diffusible protein, Slitl, to dynamically control the morphology and arrangement of the astrocytes in the migratory route, which is required for their rapid and long-range migration in the adult brain. We also found that this neuron-astrocyte interaction is also involved in the migration of new neurons into the damaged area during neuronal regeneration processes after brain infarction.

Research Products

• [Journal Article] New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. (2010)
  • Author(s): Kaneko N, Marin O, Koike M, Hirota Y, Uchiyama Y, Wu J, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein J, Sawamoto K.
  • Journal Title: Neuron 67 Pages: 212-223
  • Peer Reviewed
• [Journal Article] Musashil as a marker of reactive astrocytes after transient focal brain ischemia. (2010)
  • Author(s): Oki K, Kaneko N, Kanki H, Imai T, SuzukiN, Sawamoto K, Okano H.
  • Journal Title: Neuroscience Research 66 Pages: 390-395
  • Peer Reviewed
• [Journal Article] Adult neurogenesis and its alteration under pathological conditions. (2009)
  • Author(s): Kaneko N, Sawamoto K.
  • Journal Title: Neuroscience Research 63 Pages: 155-164
  • Peer Reviewed
• [Presentation] アストロサイトとの相互作用による新生ニューロン移動経路の形成・維持機構 (2010)
  • Author(s): 金子奈穂子
  • Organizer: 第9回成体脳のニューロン新生懇談会(招待講演)
  • Place of Presentation: 東京医科大学,東京都
  • Year and Date: 2010-11-27
• [Presentation] 精神疾患と神経幹細胞の機能 (2010)
  • Author(s): 金子奈穂子
  • Organizer: 星薬科大学認定薬剤師研修制度講演会シリーズ第2回講座・科学的根拠に基づくファーマシューティカルケアの実践を目指して(招待講演)
  • Place of Presentation: 星薬科大学,東京都
  • Year and Date: 2010-08-22
• [Presentation] Rubenstein, Kazunobu Sawamoto Dynamic interaction of migrating neurons with glial cells in adult brain. (2010)
  • Author(s): Naoko Kaneko, Oscar Marin, Masato Koike, Yuki Hirota, Yasuo Uchiyama, Jane Y Wu, Qiang Lu, Marc Tessier-Lavigne, Arturo Alvarez-Buylla, Hideyuki Okano, John L.R.
  • Organizer: 第9回日本再生医療学会総会(第2回日本再生医療学会Young Investigator's Award 受賞者講演)
  • Place of Presentation: 国際会議場,広島県
  • Year and Date: 2010-03-18
• [Book] Neurogenesis in the adult brain, (Neuronal migration in the adult brain.)
  • Author(s): Sawada M, Shi-hui Huang, Yuki Hirota, Kaneko N, Sawamoto K.
  • Publisher: Springer(in press)