2010 Fiscal Year Final Research Report

The effect of salt intake on the development of obesity in the metabolic syndrome model rats.

Research Project

Project/Area Number	20700608
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Eating habits, studies on eating habits
Research Institution	Mukogawa Women's University
Principal Investigator	YASUI Naomi Mukogawa Women's University, 薬学部, 助教 (70399145)
Project Period (FY)	2008 – 2010
Keywords	メタボリックシンドローム / 肥満 / 食塩
Research Abstract	Nowadays, metabolic syndrome and its complications have been emphasized as an important social problem. Salt intake is one of the important environmental risks for the development of life-style related diseases. In the present study, we investigated the effect of salt loading on renal damage in SHRSP.ZF and explored the underlying mechanisms. SHRSP.ZF received drinking water supplemented or not with 1% NaCl for 4 weeks developed severe hypertension, massive proteinuria, and advanced renal lesions compared with lean littermates (Lean) and SHRSP.ZF without salt loading. Obesity induces macrophage accumulation in adipose tissue. Monocyte chemoattractant protein 1 (MCP-1) is released by adipose tissue. Serum MCP-1 level was significantly higher in SHRSP.ZF than that in Lean. Complications in life-style related diseases may be caused enhanced MCP-1, partially by certain adipocyte-derived factors, contributes to the development of salt sensitive hypertension in metabolic syndrome.

(3 results)