2009 Fiscal Year Final Research Report

Nutritional improvement and change of plasma biological markers by dietary oligopeptides in rats with intestinal injury by 5-fluorouracil

Research Project

Project/Area Number	20700610
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Eating habits, studies on eating habits
Research Institution	Notre Dame Seishin University
Principal Investigator	SHIRAGA Toshiyuki Notre Dame Seishin University, 人間生活学部, 准教授 (70363596)
Project Period (FY)	2008 – 2009
Keywords	食と栄養 / ペプチド栄養
Research Abstract	It is known that small intestinal oligopeptide absorption is maintained in rats with intestinal injury by 5-fluorouracil. Recent study showed that plasma albumin and albumin/globulin ratio were improved in intestinal injured rats fed diets containing 14% soy protein isolates and especially oligopeptides. The aim of this study was to investigate plasma biological markers associated with a nutritional improvement in these rats. As a result, several plasma markers such as cytokines were changed among intestinal injured rats fed test diets. The interleukin-6 and -10 tended to decrease in rats fed soy oligopeptide diet compared with those fed casein diet. It is, therefore, suggested suppression of an intestinal injury by oligopeptide diet and maintenance of an intestinal peptide absorption caused an improvement of nutritional status in injured rats.

(2 results)