2010 Fiscal Year Final Research Report
Preventive effects of functional polyphenols on metabolic disease.
| Project/Area Number |
20700612
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Yonezawa women's junior college |
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Principal Investigator |
KURAKANE Shizue Yonezawa women's junior college, 健康栄養学科, 助手 (20442014)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ポリフェノール / サルナシ / 糖尿病 / 肥満 / α-グルコシダーゼ |
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| Research Abstract |
Actinidia arguta polyphenols (AP) inhibitedα-glucosidase activity in vitro. The oral administration of AP with maltose and starch suppressed postprandial hyperglycemia involved the intake of the respective sugars by rats. A fraction contained isoquercitrin and hyperoside as major components of AP showed a stronger inhibitory activity for maltase. The improvement of glucose intolerance and increase in the CPT activity in the liver of KK-Ay mice fed with AP or isoquercitrin suggested that the suppression of gluconeogenesis and the enhancement ofβ-oxidation of lipids as well as the inhibition of maltase by AP and isoquercitrin might also be related to their anti-diabetic effects.
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