2009 Fiscal Year Final Research Report
The role of Tumor Necrosis Factor-α in the development of radiation sickness
| Project/Area Number |
20710042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Kouichi Osaka University, 大学院・医学系研究科, 助教 (40362694)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 倦怠感 / 放射線 / 抗がん剤 / ラット / グルタミン酸 / 腫瘍壊死因子-α / シクロオキシゲーゼ |
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| Research Abstract |
We found docetaxel and cyclophosphamide induced fatigue in rats, but COX-2 inhibitor efficiently inhibited only docetaxel-induced fatigue. Although COX-2 was increased by docetaxel, not COX-2 but TNF-α was significantly increased by cyclophosphamide. These results suggested that fatigue by docetaxel and cyclophosphamide was attributed etiologically to COX-2, and TNF-α, respectively.
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