2010 Fiscal Year Final Research Report
Functional analysis of novel genes related to the mechanism of radiation-induced mammary carcinogenesis
| Project/Area Number |
20710049
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
IMAOKA Tatsuhiko National Institute of Radiological Sciences, 放射線防護研究センター, 主任研究員 (40356134)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 放射線発がん / 乳がん / 遺伝子機能解析 / siRNA / RNA干渉 / がん細胞株 |
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| Research Abstract |
This study suggests that the NRARP gene, which is overexpressed in radiation-induced rat mammary carcinoma, plays a crucial role in proliferation of human breast cancer cells, probably via regulation of the cell cycle. Since NRARP is important in intracellular signaling and regulation of developmental processes, it may be also relevant in the mechanism of radiation-induced mammary carcinogenesis.
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[Journal Article] Recent advances in the biology of heavy-ion cancer therapy.2010
Author(s)
Nobuyuki Hamada, Tatsuhiko Imaoka, Shinichiro Masunaga, Toshiyuki Ogata, Ryuichi Okayasu, Akihisa Takahashi, Takamitsu Kato, Yasuhiko Kobayashi, Takeo Ohnishi, Koji Ono, Yoshiya Shimada, Teruki Teshima
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Journal Title
Journal of Radiation Research 51(4)
Pages: 365-383
Peer Reviewed
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