2009 Fiscal Year Final Research Report
Construction of genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.
| Project/Area Number |
20710154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied genomics
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| Research Institution | Kitasato University |
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Principal Investigator |
KOMATSU Mamoru Kitasato University, 北里生命科学研究所, 研究員 (40414057)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 産業微生物ゲノム |
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| Research Abstract |
We investigated production of several exogenous secondary metabolites in genome-minimized S.avermitilis SUKA. The results revealed that the microorganism has high-level productivity for aminoglycoside, polyketide, peptide and erpene compounds over that of native-producing microorganisms. It suggested that SUKA could be a useful heterologous host for a production of secondary metabolite with a little production.
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