2009 Fiscal Year Final Research Report
Development of RNA drugs based on artificial microRNAs
| Project/Area Number |
20710157
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
ゲノム情報科学
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIBATA Atsushi Kyushu University, 大学院・医学研究院, 学術研究員 (40467890)
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| Project Period (FY) |
2008 – 2009
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| Keywords | RNA医薬 / miRNA / 核酸 / 生体機能利用 / 発現制御 |
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| Research Abstract |
The artificial microRNAs (miRNAs) that can specifically distinguish and suppress two highly homologous genes, Smad2 and Smad3, were designed to study the potential of artificial miRNAs as therapeutic drugs. Additionally, a plasmid-based system for tissue-specific regulation system of miRNA expression was constructed, and this system was confirmed that it functioned in mouse embryonic stem (ES) cells. The transgenic mice having the miRNA regulation system generated from these ES cells are under analyses.
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