2010 Fiscal Year Final Research Report
Ubiquitous Element "Iron"-mediated Preparation of Polyfunctionalized Cyclic Compounds
| Project/Area Number |
20750071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
HATA Takeshi Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教 (40419271)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ユビキタス元素 / 鉄 / 官能基共存型反応 / グリニャール試薬 / 多官能性環状化合物 |
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| Research Abstract |
Iron reagent generated from FeCl_2 and Grignard reagent is useful for metallative cyclization of functionalized acetylenes and olefins, which subsequently enables the preparation of various kinds of polifunctionalized cyclic products. In an enyne cyclization, the quantity of the iron salt can be reduced to a catalytic level.
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[Journal Article] Iron Catalyst-Switched Selective Conjugate Addition of Grignard Reagents.α, β, γ, δ-Unsaturated Amides as a Versatile Template for Asymmetric Three-Component Coupling Process2008
Author(s)
岡田悟史, 荒山恭平, 村山隆二, 石塚匠, 原圭一, 広根直樹, 秦猛志, 占部弘和
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Journal Title
Angew.Chem.Int.Ed. 47
Pages: 6860-6864
Peer Reviewed
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