2010 Fiscal Year Final Research Report
Development of neurotoxicity risk assessment of environmental pollutant for young children
| Project/Area Number |
20760361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Civil and environmental engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKAYAMA Aki Kyoto University, 大学院・工学研究科, 准教授 (10335200)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 幼児 / 鉛 / 神経毒性 / 神経細胞 / タンパク質発現変動 / HO-2 |
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| Research Abstract |
The concentrations of Pb in blood and brain following oral doses were examined and it was found that the both concentrations were almost the same. Neuronal model cells, PC12, were exposed to lead acetate, and he protein expression patterns were examined. It was found that the expression of HO-2(heme oxygenase 2) was decreased at the concentration more then 0.5 microM. The expression of HO-2 is possibly more sensitive biomarker to Pb and could be useful for risk assessment.
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