2010 Fiscal Year Final Research Report
Neural mechanisms of age-related memory impairment in insect
| Project/Area Number |
20770053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUMOTO Yukihisa Tohoku University, 大学院・理学研究院, 研究員 (60451613)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 加齢性記憶障害 / 嗅覚学習 / 視覚学習 / 色覚学習 / 長期記憶 / 一酸化窒素 / 昆虫 |
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| Research Abstract |
In this study, I revealed that crickets show age-related memory impairment (AMI) in long-term memory (LTM) formation in three types of learning ; to associate either olfactory, visual pattern or color with water reward. The AMI in each type of learning were fully recovered by administration of agonists of NO-cGMP signaling pathway. I also revealed that in the LTM formation mechanism, nicotinic acetylcholine receptors play role upstream of NO-cGMP pathway. Additional experiments were performed to test whether degradation of NO-cGMP signaling is responsible for AMI in cricket LTM formation
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