2009 Fiscal Year Final Research Report
Analysis of undifferentiated hematopoietic cells from hematopoietic tissues of mouse embryo and role of the cells in hematopoiesis on ontogeny
| Project/Area Number |
20770181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
NOBUHISA Ikuo Kumamoto University, 難治疾患研究所, 准教授 (40332879)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 細胞分化 |
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| Research Abstract |
We try the identification of the undifferentiated hematopoietic cells on mouse embryos. In the AGM regions, which show the emergence of cells containing the long-term repopulating activity in irradiated adult mice, CD45lowc-Kithigh cells had the highest ability to form hematopoietic cell colonies in vitro. We found that CD45lowc-Kithigh cells were identified in the stages of showing hematopoiesis in the AGM regions. The CD45lowc-Kithigh cells were also identified in yolk san and fetal liver. In the placenta, the hematopoietic activity of CD45highc-Kithigh cells was highest.
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Research Products
(8 results)
